Huntington�s disease is an inherited neurodegenerative disorder, where symptomatic treatments are available for\nHuntington�s disease. The present study investigates the beneficial effect of astaxanthin as a natural carotenoid against 3-\nnitropropionic acid (3-NP) induced Huntington�s disease in male wistar rats. Findings indicates daily intraperitoneal\nadministration of 3-NP for 14 days affect body weight, brain weight and neurobehavioral deficits by motor coordination,\ndepression and memory dysfunction as well as increased oxidative stress and raised brain LDH levels. The treatment with\nastaxanthin at doses of 12.5, 25 and 50 mg/kg significantly hasten the progression and improve the body weight and brain\nweight, motor co-ordination and cognition as well as alleviate depression. Further observed more improvement in the rats\nwhich were treated with astaxanthin 50 mg/kg and these improvements were also statistically significant as compared to\nastaxanthin 12.5 mg/kg. The increased oxidative stress in the brain was significantly attenuated with the astaxanthin 25 and 50\nmg/kg dose treatment. The high levels of striatum lactate dehydrogenase in HC rats was found to be significantly lowered in the\nrats treated with astaxanthin. Histopathological examination astaxanthin 50 mg/kg treated rats striatum revealed a marked\nimprovement with less neurodegenration and absence of pyknotic nuclei compared to Huntington control rat. In conclusion,\ntreatment of astaxanthin attenuates the symptoms of Huntington�s disease which might be because of its antioxidant and\nneuroprotective activity.
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